Formulation and In-vitro evaluation of Solid Lipid Nanoparticle of Hesperidin
Swati Tiwari*,Dinesh Kumar Sharma, Arun Kumar Singh
DevsthaliVidyapeeth College of Pharmacy, Lalpur (U.S.Nagar)
E-mail- [email protected]
Most of the CNS drugs are not reaches to brain because it cannot cross the blood-brain barrier. So an attempt was made to formulate solid lipid nanoparticles (SLNs) of CNS active drugs. Hesperidin is used as a model drug, chemically a flavanon glycoside found in citrus fruits. The aim of this study was to prepare and evaluate solid-lipid nanoparticle of Hesperidin for oral delivery. Solid-lipid nanoparticle of Hesperidin, were prepared by the cold homogenization method followed by ultrasonication method. SLNs were characterized for particle size,entrapment efficiency, diffusion study, Drug Content and Transmission Electron Microscopy.From the result it was concluded that the SLN loaded hesperidine shows better permeation than, the parent drug, so the absorption of the drug is enhanced.
Key Words: Hesperidin, Solid Lipid Nanoparticle, Cold Homogenization, Ultrasonication